Tolerance of Cyto-selective Difluoroethane-based Cryotherapy

Exclusion Criteria

• •Having performed cosmetic treatments (exfoliants, scrubs or self-tanners, facials, UV ...) in the month before the start of the study, at the level of the hand.
• •Having applied a depraving product in the month prior to the start of the study, at the hands (except cleansing products).
• •Having performed cosmetic treatments in a dermatologist (laser, IPL (Intensed pulsed light), peeling, creams, cryotherapy ...), on the hands in the last 6 months.
• •With dermatosis, autoimmune disease, systemic, chronic or acute disease, or any other pathology that may interfere with treatment or influence the results of the study (people with diabetes or circulatory problems,allergic to cold, Raynaud's syndrome...).
• •Receiving treatment by general or local (dermo corticoids, corticosteroids, diuretics ...) likely to interfere with the evaluation of the parameter studied.
• •Participating in another study or being excluded from a previous study.
• •Unable to follow the requirements of the protocol.
• •Vulnerable: whose ability or freedom to give or refuse consent is limited.
• •Major protected by law (tutorship, curatorship, safeguarding justice...).
• •People unable to understand, read and write English/French/Ukrainian language. However, the impartial witness will be introduced to current study to make translations if necessary, during all course of the study for each volunteer and respective section for signature and date will be implemented to the "Information Sheet and Informed Consent Form".
• •Unable to be contacted urgently over the phone.
• •For female subjects:
• •Pregnant woman (or wishing to be pregnant during study) or while breastfeeding.
• •A woman, who does not use effective methods of contraception.