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Decline in Renal Concentration Ability in Lithium Treated Patients

NCT05307042·1 site·ClinicalTrials.gov

What this study is about

Take this into the appointment.

Saves the questions and what to expect into your notes, next to the visit they belong to.

Keep this study

M.J. van der Aa
CONTACT
(073) 553 30 71 [email protected]

Lead

Radboud University Medical Center

Age

18–any

Sex

ALL

Healthy volunteers

Not accepted

You may be eligible if

included in the previous study
men and women
age ≥ 18 years

You may not be if

General contra-indications for participation in a trial:
* inability to give informed consent
* pregnancy
* unstable psychiatric condition
Alternative causes of (nephrogenic) diabetes insipidus:
* hypokalemia (plasma potassium \< 3.0 mmol/l)
* severe hypercalcemia (albumin-corrected plasma calcium \> 2.80 mmol/l)
* hyperglycemia (plasma glucose \> 10.0 mmol/l)
* history of amyloidosis, Sjögren's syndrome or Sickle cell anemia
* previous treatment with ifosfamide
* established primary polydipsia or central diabetes insipidus
Contra-indications for dDAVP administration:
* inability to comply with water restriction
* renal insufficiency (GFR \< 45 ml/min/1.73 m2)
* hyponatremia (plasma sodium \< 130 mmol/l)
* instable angina pectoris
* decompensated cardial insufficiency
Other:
* concomitant treatment with desmopressin or democlocycline

The record

StatusUnknown

PhaseNo phase

Taking part51

StartedMay 2022

UpdatedApr 1, 2022

Conditions

Lithium Toxicities Bipolar Disorder Concentration Ability Impaired Nephrogenic Diabetes Insipidus Lithium - Induced Nephropathy

Where1

Canisius Wilhelmina Ziekenhuis
Nijmegen, Gelderland, Netherlands

Clareo Health | Decline in Renal Concentration Ability in Lithium Treated Patients