A Study on Radiation Therapy Guided by the Reflectance Confocal Microscopy (RCM)/Optical Coherence Tomography (OCT) Device in People With Basal Cell Carcinoma

Inclusion Criteria

• •Biopsy proven basal cell carcinoma
• •°Up to 3 tumors per patient can be treated per protocol synchronously or metachronously
• •Clinical stage T1 or T2 by Union International to Control Cancer 8th edition system
• •* ≤40 mm in maximum dimension
• •* no deep invasion (beyond subcutaneous fat or \>6 mm from granular later of dermis to deepest point of carcinoma)
• •* no perineural invasion of nerves ≥0.1 mm diameter or deeper than dermis
• •* no intraneural invasion
• •* no bone erosion, invasion or foraminal transgression NOTE: For the purposes of protocol inclusion, if any of the features mentioned above is not included in the pathology report they will considered absent.
• •≥18 years old
• •Amenable to RCM/OCT and radiation therapy in opinion of investigator
• •* Some anatomic locations may preclude imaging by RCM/OCT may not be amenable to RCM/OCT imaging
• •* Some medical comorbidities may preclude the delivery of radiation therapy (conditions rendering patients hypersensitive to ionizing radiation, or unable to undergo treatment)
• •Able and willing to complete the Skindex 16 and Skin Cancer Index (must be able to understand English or Spanish)