Effects of 10-gram Collagen Protein Hydrolysate on Cardiometabolic Health

Inclusion Criteria

• •Aged between 40-75 years
• •Men and women (in a ratio of 40/60 to 60/40)
• •BMI between 25-35 kg/m2
• •Serum total cholesterol \< 8.0 mmol/L (further testing is recommended for excessive hyperlipidemia \[serum total cholesterol ≥ 8.0 mmol/L\] according to the Standard for cardiovascular risk management of the Dutch general practitioner's community \[Nederlands Huisartsen Genootschap\])
• •Serum triacylglycerol \< 4.5 mmol/L
• •No current smoker
• •No diabetic patients
• •No familial hypercholesterolemia
• •No abuse of drugs
• •Not more than 4 alcoholic consumption per day with a maximum of 21 per week??
• •Stable body weight (weight gain or loss \< 3 kg in the past three months)
• •No use of medication known to treat blood pressure, lipid or glucose metabolism
• •No use of an investigational product within another biomedical intervention trial within the previous 1-month
• •No severe medical conditions that might interfere with the study, such as epilepsy, asthma, kidney failure or renal insufficiency, chronic obstructive pulmonary disease, inflammatory bowel diseases, autoinflammatory diseases, and rheumatoid arthritis
• •No active cardiovascular disease like congestive heart failure or cardiovascular events, such as an acute myocardial infarction or cerebrovascular accident
• •Willingness to give up being a blood donor from 8 weeks before the start of the study, during the study, and for 4 weeks after completion of the study
• •No difficult venipuncture as evidenced during the screening visit
• •Willing to comply to study protocol during the study
• •Agree to take porcine / animal-derived supplements (i.e. collagen)
• •Informed consent signed