Ivabradine for Prevention of Myocardial Injury After Noncardiac Surgery Trial (PREVENT-MINS)

Exclusion Criteria

• •1. Conduction abnormalities:
• •A. Non-sinus rhythm on ECG B. Sinoatrial or AV (2nd and 3d degree) blocks C. Sick sinus syndrome D. Long QT syndrome E. Pacemaker dependent
• •2. Transplanted heart (or on waiting list)
• •3. Use of a selected class I or III antiarrhythmic drug (quinidine, disopyramide, sotalol, ibutilide, amiodarone) or diltiazem/verapamil
• •4. Resting heart rate \<65 beats per minute on the day of surgery
• •5. Systolic blood pressure \<90 mmHg on the day of surgery
• •6. Acute decompensated heart failure, cardiogenic shock, acute myocarditis
• •7. Acute coronary syndrome within 2 months before surgery;
• •8. Stroke or transient cerebral ischaemia within 1 month before surgery
• •9. Known severe liver or kidney disease (MDRD creatinine clearance \<15 mL/min)
• •10. Inability to tolerate oral intake
• •11. Recent use of ivabradine (\<1 month)
• •12. Known allergy or hypersensitivity to ivabradine
• •13. Low-risk surgical procedure based on individual physician's judgment
• •14. Investigator considers the patient unreliable regarding requirement for study compliance
• •15. Women of childbearing potential who are not taking effective contraception, pregnant or breast-feeding
• •16. Previously enrolled in the PREVENT-MINS study