Lead Sponsor

Centre Hospitalier Universitaire, Amiens

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

•Patients scheduled for major abdominal surgery (defined as surgery with a risk of cardiovascular complications of \>1% and/or lasting more than 2 hours) with general anaesthesia.
•American Society of Anesthesiologists physical status (ASA-PS) score of ≥2.
•Age of ≥50 years and weighing more than 50 kg
•Written informed consent.

•Emergency surgery.
•Untreated or uncontrolled hypertension (systolic blood pressure of \>150 mm Hg), despite medication.
•Any acute cardiovascular event, including acute or decompensated heart failure or acute coronary syndrome.
•Patients with chronic kidney disease with a glomerular filtration rate of \<30 ml.min-1/1.73 m2 or requiring renal replacement therapy for end-stage renal disease.
•Patients with severe hepatic failure (ASAT/ALAT of \>2N, elevated bilirubin level, PT of \<50%).
•Preoperative sepsis, septic shock.
•Preoperative norepinephrine infusion.
•Patients eligible for a surgical procedure under locoregional anaesthesia.
•Pregnancy.
•Known allergy to study treatment.
•Patients unable to give informed consent for any reason.