Unable to tolerate ACEI/ARB class antihypertensive drugs;

History of symptomatic hypotension/systolic blood pressure \<100mmHg at screening;

Potassium \>6.0mmol/L;

History of angioedema;

Abnormal liver function such as ALT and/or AST \>=3 times normal upper limit (ULN), total bilirubin \>= 2 times ULN;

Moderate to severe anemia (hemoglobin \<80g/L);

Cardiac surgery/intervention/cardiac resynchronization therapy has been performed in the past 3 months or is planned in the next 12 months;

Newly found malignant tumor (within 3 years), or undergoing radiotherapy/chemotherapy;

Pregnant and lactating women, or those of childbearing age who are unable to guarantee effective contraception;

New and serious life-threatening infections;

Active infectious diseases such as active tuberculosis, active viral hepatitis and HIV infection;

Persons suffering from mental disorders and taking psychotropic drugs;

Patients with life expectancy less than 12 months;

The doctor assessed that the patient was not easy to follow up or had poor compliance and was not suitable for enrollment;

Patients who do not want to sign informed consent.

Sacubitril/Valsartan for CKD5 Stage Dialysis Patients