definite MS diagnosis according the 2017 revised McDonald criteria
disease course: PPMS according to the 2013 revised Lublin criteria
disease severity: Expanded Disability Status Scale (EDSS) score ≤ 6.0
Informed Consent as documented by signature of participants and PI
You may not be if
Persons suffering from severe lower extremity spasticity or severe concomitant ´ disease states (i.e., orthopaedic, cardiovascular, metabolic, psychiatric (e.g., substance abuse), other neurological, other serious medical conditions) impairing their ability to participate.
Persons regularly performing HIIT (2-3 times per week)
Inability to follow the procedures of the study due to language problems (i.e., participant not fluent in oral and written German language)
Intention to become pregnant during the course of the study
Suspected non-compliance
Previous enrolment into the current study
Enrolment of the investigator, his/her family members, employees, and other dependent persons
occurrence of severe pulmonary or cardiovascular decompensations (i.e., blood pressure (Riva Rocci) \> 240/120, HR ≥ HRmax (220-years of age) (e.g. due to renal failure, hepatic dysfunction, cardiovascular disease)
abnormalities in electrocardiography (ECG), pulse oximetry, or spirometry during initial CPET
Clareo Health | The Influence of HIIT Versus MCT on Cardiorespiratory Fitness in PPMS
