Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Clover Biopharmaceuticals AUS Pty
Age
18–75
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
Male or female 18 to 75 years of age
Individuals are willing and able to comply with study requirements, including all scheduled visits, vaccinations, laboratory tests and other study procedures
Individuals are willing and able to give an informed consent, prior to screening
Healthy participants or participants with pre-existing medical conditions who are in a stable medical condition.
Female participants of childbearing potential may be enrolled in the study, if the participant has practiced highly effective method of contraception for 30 days prior to vaccination and has a negative pregnancy test on the day of vaccination and has agreed to continue adequate contraception for 3 months after the last vaccination
Male participants must agree to employ acceptable contraception from the day of the first dose of the study vaccine until 6 months after the last dose of the study vaccine and also refrain from donating sperm during this period
You may not be if
Individuals with body temperature \>37.8°C (axillary), or any acute illness at baseline (Day 1) or within 3 days prior to randomization.
Body mass index at screening \>30 kg/m2
Individuals with laboratory-confirmed SARS-CoV-2 infection \[as defined by reverse transcriptase polymerase chain reaction (RT-PCR) assay or Rapid COVID Antigen Test or an equivalent\] at the screening visit or with known history of COVID-19 within 6 months prior to Day 1
Individuals who have received an investigational or authorized COVID-19 vaccine within 6 months prior to Day 1, or plan to receive COVID-19 vaccine during the study period
Any confirmed or suspected immunosuppressive or immunodeficient condition resulting from disease \[e.g., malignancy, human immunodeficiency virus (HIV) infection\] or immunosuppressive/cytotoxic therapy (e.g., systemic corticosteroids, medications used for cancer chemotherapy, organ transplantation or to treat autoimmune disorders) within 3 months prior to Day 1.
Individuals with any progressive unstable or uncontrolled clinical conditions
Individuals who are pregnant, or breastfeeding, or planning to become pregnant while enrolled in this study or during the study period
Individuals who have a history of severe adverse reaction associated with a vaccine or severe allergic reaction, e.g., anaphylaxis to any components of the study vaccines
Individuals who have a history of malignancy within 1 year before screening (exceptions are squamous and basal cell carcinomas of the skin and carcinoma in situ of the cervix which have been cured, or other malignancies with minimal risk of recurrence).
Individuals who have received any other investigational product within 30 days prior to Day 1 or intend to participate in another clinical study at any time during the conduct of this study
Individuals who have received any other licensed vaccines within 14 days prior to enrollment in this study or who are planning to receive any vaccine up to 28 days after the second vaccination
Individuals with known bleeding disorder that would, in the opinion of the investigator, contraindicate i.m. injection
Individuals who have received treatment with rituximab or any other anti-CD20 monoclonal antibodies within 9 months prior to Day 1 or planned during the study period
Administration of intravenous immunoglobulins and/or any blood products within 3 months prior to enrollment or planned administration during the study period
Individuals with positive test result for hepatitis B surface antigen, hepatitis C virus antibody, or human immunodeficiency virus types 1 or 2 antibodies at Screening
Individuals with safety laboratory test results (hematology, biochemistry, and coagulation) with a toxicity score of Grade ≥2 at Screening.
The participant has a reported or documented history of alcohol abuse or drug addiction (excluding nonprescription health supplements and herbal remedies) within 1 year before the planned day of dose administration
The participant has a positive test result for drugs of abuse at Screening
Individuals with any condition that, in the opinion of the investigator, would interfere with the primary study objectives or pose additional risk to the participant
Clareo Health | Safety and Immunogenicity Dose-finding Study of Adjuvanted SCB-2020S Vaccine in Adults
