Preoperative Ultra-hypofractionated Radiotherapy Followed by Surgery for Retroperitoneal Sarcoma (FUSION-01)

Inclusion Criteria

• •Primary soft tissue sarcoma of retroperitoneal or infra-peritoneal spaces of pelvis
• •Sarcoma not originated from bone structure, abdominal or gynecological viscera
• •All disease can be included safely within one radiotherapy field
• •Absence of extension through the sciatic notch or across the diaphragm
• •Histologically proven, excluding the following subtypes: Gastro-intestinal stromal tumors (GIST), rhabdomyosarcoma, PNET or other small round blue cells sarcoma, osteosarcoma or chondrosarcoma, aggressive fibromatosis, sarcomatoid or metastatic carcinoma
• •ECOG performance status 0 to 2
• •American Society of Anesthesiologist (ASA) score ≤2
• •Normal renal function: Calculated Creatinine Clearance ≥50ml/min（by Cockcroft-Gault formula）and functional contralateral kidney by differential renal isotope scan
• •Normal bone marrow and hepatic function.
• •Contraception was needed for female patients of child-bearing age, or male patients whose partner had child-bearing age
• •expected life expectancy longer than 5 years
• •Written consent form was given prior to treatment
• •Can safely be treated by radiotherapy and surgery