Study of Exploratory Plasmatic Markers of Alcohol Withdrawal

Exclusion Criteria

• •Active use disorder of benzodiazepines, delta-9-tetrahydrocannabinol (THC), opioids, cocaine, amphetamines, new synthetic drug, gamma-hydroxybutyrate/gamma-butyrolactone, hallucinogens, assessed by interview
• •Use in the previous 30 days of THC, opioids, cocaine, amphetamines, a new synthetic product, gamma-hydroxybutyrate/gamma-butyrolactone, hallucinogenic substances, assessed by questioning or positive by urine test,
• •Patient on opioid maintenance therapy (methadone or buprenorphine)
• •Presence of decompensated cirrhosis (Child Pugh score B or C) on admission or liver insufficiency with a TP \< 70%,
• •Presence of severe acute alcoholic hepatitis (Maddrey score ≥32) on admission,
• •Presence of chronic renal failure with a glomerular filtration rate of less than 60mL/minute/1.73m2 estimated by the Cockroft formula,
• •Presence of acute renal failure,
• •Presence of another condition that may cause brain damage :
• •epileptic seizure, stroke, head trauma within the last three months,
• •previously diagnosed severe cognitive impairment
• •history or active infection with HIV, hepatitis C virus (HCV) or syphilis, known and noted in the medical record, collected in the history or noted in the systematic screening for sexually transmitted infections carried out for care,
• •Patient with a language barrier (unable to follow the protocol or respond to clinical assessments),
• •Hospitalization expected to be less than 15 days and not able to perform the protocol assay at D14,
• •Pregnant, parturient or breastfeeding women,
• •Person deprived of liberty by judicial or administrative decision,
• •Person hospitalised without consent and not subject to a legal protection measure,
• •Person subject to an exclusion period for other research,
• •Adult person subject to a legal protection measure, adult person unable to express his or her consent and not subject to a protection measure.