Multicentric, observational, single arm, prospective, study.
All patients will undergo imaging assessments according to clinical practice or to Lu-PSMA Tumor Institute of Romagna (IRST) 185.03 protocol, as follows:
* Baseline, before the treatment with Lu-PSMA, CT and WB-MRI will be performed
* At the end of treatment with Lu-PSMA, CT and WB-MRI will be performed
* In post-treatment follow-up every 4 months, until progression or for 1 year, CT and WB-MRI will be performed.
Patients participating in this observational study will not be subjected to any additional procedure that falls outside the clinical practice or the study 185.03 Lu-PSMA trial at IRST.