Investigating Central Neurophysiologic Correlates of Non-Motor Symptoms of Parkinson's Disease

Exclusion Criteria

• •Inability to provide informed consent.
• •Severe dementia
• •History of epilepsy or brain surgery
• •Severe tremor or dyskinesia that would interfere with EEG as determined by the PI
• •Parkinson's patients with clinically significant medical or neurological conditions which may be an alternative cause of orthostatic hypotension, such as neuropathy, renal failure, heart failure, cardiac arrhythmias, severe diabetes, or spinal cord injuries
• •The investigators will exclude patients who are treated with medications which can significantly lower blood pressure or heart rate, such as antihypertensive medications, diuretics, and alpha-blocking medications
• •Presence of other known central nervous system disease that may interfere with performance or interpretation of EEG or TMS
• •Presence of any implanted metal devices including, but not limited to, pacemakers, deep brain stimulators, vagal nerve stimulators, bladder stimulators, or cochlear implants.