THE TRAVEL II TRIAL: Transcatheter Right Atrial-ventricular Valve rEplacement With LuX-Valve Via Jugular Vein

Exclusion Criteria

• •1. Subjects with pulmonary hypertension (systolic pressure ≥ 55mmHg determined by right heart catheterization).
• •2. Subjects with previous transcatheter or surgical tricuspid valve procedure.
• •3. Subjects with tricuspid stenosis or other anatomy disorders that unsuitable for the procedure.
• •4. Subjects with depressed right heart function (tricuspid annular plane systolic excursion (TAPSE) \< 10mm or right ventricle fractional area change (FAC) \< 20%).
• •5. Subjects with aortic stenosis (mean ΔP≥ 40mmHg or aortic valve area ≤ 1 cm2), aortic regurgitation (≥ 3+), mitral stenosis (mitral valve area ≤1.5 cm2) or mitral regurgitation (≥ 3+).
• •6. Subjects with active endocarditis or other infectious diseases.
• •7. Subjects with untreated severe coronary artery disease.
• •8. Subjects with percutaneous coronary intervention, cerebrovascular accident or surgical intervention within 3 months of the date of the procedure.
• •9. Subjects with coagulation disorders.
• •10. Subjects with known allergy, hypersensitivity or contraindication to the material or drugs used in the procedure.
• •11. Subjects with cognitive disorders that can not cooperate the study or follow-up.
• •12. Subjects with less than 12 months life expectancy because of non-cardiac conditions.