KAP for Depression in Abstinent Opioid Users

Exclusion Criteria

• •Subjects will be excluded from the study if any of the following criteria apply:
• •1. They are considered an immediate suicide risk by clinician assessment, self-reports a suicide attempt within the past year, or felt to be likely to require hospitalization during the study.
• •2. Subjects who meet DSM-5 criteria for current bipolar disorder based on clinical interview.
• •3. Subjects who meet DSM-5 criteria for current or history of psychotic spectrum disorders based on clinical interview.
• •4. Subjects meeting DSM-5 criteria for current substance use disorder (i.e., not in early or sustained remission) other than tobacco use disorder.
• •5. Subjects who report use of ketamine \>20 times in the past or who meet DSM-5 criteria for Other Hallucinogen Use Disorder due to ketamine use including subjects who are currently in early or sustained remission.
• •6. Women who are pregnant or nursing, and women who do not consent to use methods of highly effective birth control during the interventional phase of the study.
• •7. Subjects with hypertension as defined by a baseline visit systolic blood pressure (SBP) \>140 mmHg or a diastolic blood pressure (DBP) \>90 mmHg.
• •8. A history of allergic or other adverse reaction to ketamine (or its excipients).
• •9. Clinically significant physical exam findings or self-reported medical conditions for which a transient increase in blood pressure could be significantly detrimental (e.g. glaucoma, aneurysmal disease, cardiovascular disease, or end-stage renal disease).
• •10. QTc will be measured in all subjects and those with QTc 450ms or longer will be excluded.
• •11. Subjects who live greater than 20 miles from the study site and cannot arrange their own transportation will be excluded from the study.
• •12. Subjects with kidney or liver impairment.