Brain Circuitry Analysis in Bipolar Disorder

Exclusion Criteria

• •1. Acute medical condition or \>3 stable, chronic health conditions
• •2. Significant structural brain lesion
• •3. Progressive neurological disease
• •4. Preexisting implanted electrical device
• •5. Currently pregnant or planning to become pregnant
• •6. Contraindications to MR imaging
• •7. Tests positive for cannabis, illegal substances, or prescription medications without valid prescription
• •8. Currently taking steroids, opioids, or other agents that might affect brain circuitry per research team discretion
• •9. Use of cigarettes or other nicotine products within 12 hours of imaging visit
• •10. Use of stimulants 24 hours prior MRI visit
• •11. Presents an immediate danger to self or others as judged by research psychiatrist
• •12. Has psychiatric disorder, including alcohol/drug use disorder or personality disorder
• •Group 2: Treatment-Responsive BDI
• •1. Acute medical condition or \>3 stable, chronic health conditions
• •2. Significant structural brain lesion
• •3. Progressive neurological disease
• •4. Preexisting implanted electrical device
• •5. Currently pregnant or planning to become pregnant
• •6. Contraindications to MR imaging
• •7. Tests positive for cannabis, illegal substances, or prescription medications without valid prescription
• •8. Currently taking steroids, opioids, or other agents that might affect brain circuitry per research team discretion
• •9. Use of cigarettes or other nicotine products within 12 hours of imaging visit
• •10. Use of stimulants within 24 hours of imaging visit
• •11. Presents an immediate danger to self or others as judged by research psychiatrist
• •12. Has had changes in medications within 30 days
• •13. Contribution of any co-occurring psychiatric comorbidity disproportionate to contribution of BDI or BDII
• •14. Meets DSM-5 criteria for current borderline or antisocial personality disorder
• •15. Meets DSM-5 criteria for alcohol and/or drug use disorder within 6 months, excluding caffeine and/or nicotine
• •Group 3: Treatment-Refractory BDI
• •1. Acute medical condition or \>3 stable, chronic health conditions
• •2. Significant structural brain lesion
• •3. Progressive neurological disease
• •4. Preexisting implanted electrical device
• •5. Currently pregnant or planning to become pregnant
• •6. Contraindications to MR imaging
• •7. Tests positive for cannabis, illegal substances, or prescription medications without valid prescription
• •8. Currently taking steroids, opioids, or other agents that might affect brain circuitry per research team discretion
• •9. Use of cigarettes or other nicotine products within 12 hours of imaging visit
• •10. Use of stimulants within 24 hours of imaging visit
• •11. Presents an immediate danger to self or others as judged by research psychiatrist
• •12. Has had changes in medications within 30 days
• •13. Contribution of any co-occurring psychiatric comorbidity disproportionate to contribution of BDI or BDII
• •14. Meets DSM-5 criteria for current borderline or antisocial personality disorder
• •15. Meets DSM-5 criteria for alcohol and/or drug use disorder within 6 months, excluding caffeine and/or nicotine