Risk and Benefits of Electronic Cigarettes to Older Smokers at High Risk for Lung Cancer

PRIMARY OBJECTIVE: I. To characterize the effects of switching from combustible cigarettes (CCs) to e-cigarettes (ECs) on product use, product acceptability, and reinforcement among adult daily CC smokers at high risk for lung cancer. EXPLORATORY OBJECTIVES: I. To characterize the effects of switching from CCs to ECs on biomarkers of inflammation and oxidative stress among adult daily CC smokers at high for lung cancer. II. To characterize metabolomic changes that result from switching from CCs to ECs among CC smokers at high risk for lung cancer III. To characterize which factors moderate or mediate the effects of switching from CCs to ECs among CC smokers at high risk for lung cancer OUTLINE: Participants are assigned to switch to e-cigarettes. Participants vape study-provided e-cigarettes for 26 weeks. Participants use smartphone to answer questions about nicotine cravings and mood and log daily smoking activity every day for up to 26 weeks. Participants complete questionnaires over 30-45 minutes and undergo collection of urine and blood samples on study.