Pinpoint Trial: Prebiotics IN Peanut Oral ImmunoTherapy

Exclusion Criteria

• •• History of a chronic disease (other than asthma, allergic rhinitis, and atopic dermatitis) that is at significant risk of becoming unstable or requiring a change in chronic therapeutic regimen
• •* History of mast cell disease
• •* History of recurrent idiopathic or virally induced urticaria, angioedema or anaphylaxis
• •* Any history or presence of autoimmune, cardiovascular disease, chronic lung disease (other than asthma), malignancy, psychiatric illness, or gastrointestinal inflammatory conditions, including celiac disease, inflammatory bowel disease, eosinophilic esophagitis or other eosinophilic gastrointestinal disease
• •* Current participation in any other interventional study
• •* Subject who has undergone any type of oral immunotherapy
• •* Severe asthma or uncontrolled mild to moderate asthma
• •* Uncontrolled atopic dermatitis
• •* Current use of oral steroid medications
• •* Use of \>1 bursts of oral steroid medications in the past year
• •* Inability to eat by mouth the fiber supplementation or placebo control and peanut flour for any reason
• •* Use of any therapeutic antibody (biologic medication) or any immunomodulatory medication in the past 12 month (other than a short course of oral steroids)
• •* Current use of any type of immunotherapy
• •* Pregnancy or lactation
• •* Allergy to potato or corn oat or cow's milk
• •* Unwillingness to carry an epinephrine auto-injector
• •* Unwillingness to comply with activity restrictions during OIT or any other study procedure