A Study of CIN-107 in Patients With Uncontrolled Hypertension

Exclusion Criteria

• •Has a mean seated systolic blood pressure (SBP) ≥180 mmHG;
• •Has a body mass index (BMI) \>50 kg/m2;
• •Is using alpha or beta blockers for any primary indication other than systemic hypertension (eg, migraine headache);
• •Is not willing or not able to discontinue an MRA or potassium sparing diuretic as part of an existing antihypertensive regimen;
• •Has documented estimated eGFR \<30 mL/min/1.73m2;
• •Has known and documented New York Heart Association stage III or IV chronic heart failure;
• •Has had a stroke, transient ischemic attack, hypertensive encephalopathy, acute coronary syndrome, or hospitalization for heart failure within 6 months before screening;
• •Major cardiac surgery within 6 months before Screening;
• •Has chronic permanent atrial fibrillation;
• •Has uncontrolled diabetes with glycated hemoglobin \>10% at Screening;
• •Has planned dialysis or kidney transplantation planned during the course of the study;
• •Prior solid organ transplant and/or cell transplants;
• •Sodium \<130 mEq/L;
• •Potassium \<3.5 mEq/L;
• •Potassium \>5 mEq/L;
• •White blood cell count \>15 × E9/L or absolute neutrophil count \<1 × E9/L at Screening;
• •Is positive for HIV antibody, hepatitis C virus RNA, or hepatitis B surface antigen;
• •Has typical consumption of ≥14 alcoholic drinks weekly;