Evoked Responses as Pharmacodynamic Biomarkers in Healthy and Schizophrenic Participants (MK-4334-007)

Inclusion Criteria

• •HC Participants:
• •Is in generally good health
• •Has no history of clinically relevant neuropsychiatric illness
• •Is a mild-to-moderate tobacco user of ≥1-year duration, smoking the equivalent of \~10-15 cigarettes/day
• •Participants with Mild-to-Moderate SZ:
• •Has a current diagnosis of SZ with a duration ≥1 year
• •Is clinically stable and in the residual (non-acute) phase of illness for ≥12 weeks prior to the study
• •Is stably maintained on a regimen of up to 2 first- or second-generation antipsychotics with no dose changes \>50% in combination with concomitant medication commonly prescribed to this population for ≥8 weeks prior to screening and during the study
• •Is a mild-to-moderate tobacco user of ≥1-year duration, smoking the equivalent of \~10-15 cigarettes/day
• •All Participants:
• •For males, agrees to be abstinent from heterosexual intercourse, or use an approved contraception method, during the study and for 90 days after the last dose of study drug
• •For females, is not of childbearing potential
• •Is willing to comply with restrictions on the use of nicotine or nicotine-containing products during the study