Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Memorial Sloan Kettering Cancer Center
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Patients with Stage IV metastatic HER2+ breast cancer without CNS disease s/p 1 or more lines of HER2 directed therapy (Cohort A Only)
Patients with Stage II-III HER2+ breast cancer without CNS disease (Cohort B Only)
Male and Female participants Age ≥18 years
HER2+ as defined by ASCO/CAP guidelines\*
Ability to undergo bedside Lumbar puncture to obtain cerebrospinal fluid; if beside LP is not successful due to patient discomfort or inability to obtain spinal fluid then patients will be offered LP through interventional radiology and patients will continue to be monitored on study
Able to provide written informed consent \*ASCO/CAP guidelines: HER2+ defined as IHC 3+ positive and/or by ISH average copy number ≥ 6 signals/cell
You may not be if
Patients who are unable to undergo MRI with gadolinium
Patients with CNS Metastases on Screening MRI
Patients with Positive Cytology on Screening Bedside lumbar puncture
Clareo Health | Monitoring for Cancer Spread to the Central Nervous System (CNS) in People With Breast Cancer
