Quantitative Assessment of Radiation-induced Neuroinflammation - A Proof of Principle Study

Exclusion Criteria

• •Participants with a large pseudomeningocele (\>4 cm in size) at the surgical site, complications from ventricular access (evidenced by hemorrhage and/or enhancement along the catheter), large subdural effusion in the supra-tentorial compartment (\>1 cm in the maximum transverse dimension). All of these are expected to induce inflammation.
• •Female participants of childbearing age must not be lactating due to theoretical potential harm to the infant from exposure to radiation.
• •Subjects with low-affinity TSPO binding sites as determined by the single-nucleotide polymorphism (SNP) rs6971 in the TSPO gene.
• •Pregnant subjects.
• •Patients needing sedation for the PET scans or optional MRI scans.
• •Participants with a diagnosis of recurrent medulloblastoma.