Pharmacokinetic Characteristics, Safety, Tolerability and Immunogenicity of LY01008 and Avastin in Healthy Chinese Male Subjects

Exclusion Criteria

• •Subjects with evidence or history of clinically significant disease
• •Subjects with a history of previous cancer
• •Subjects with a history of hypertension, or abnormal blood pressure at screening/baseline measurements (systolic blood pressure \> 140 mmHg and/or diastolic blood pressure \> 90 mmHg confirmed by a repeat measurement on the same day)
• •Subjects with a history of blood donation 3 months before study drug infusion
• •Subjects with a history of exposure to antibodies 12 months before study drug infusion
• •Subjects with previous exposure to anti-VEGF therapy