Investigation of the Efficacy and Tolerability of a Cosmetic Product With Onabotulinumtoxin A in the Treatment of Facial Lines

Inclusion Criteria

• •1. Female subjects must be between 35-60 years of age.
• •2. Female subjects of childbearing potential must be willing to use a form of birth control during the study.
• •3. Subjects with Fitzpatrick I-VI photo skin type.
• •4. Subjects must have moderate to severe crow's feet facial wrinkles (score 4-7 on 0-9 scale) using modified Griffith's 10-point scale.
• •5. Subjects must have moderate to severe crow's feet fine lines (score 4-7 on 0-9 scale) using modified Griffith's 10-point scale.
• •6. Subjects may have mild to moderate photo-aging (score 3-6 on 0-9 scale) secondary to physiologic aging, hormonal influences, and environmental stressors.
• •7. Subjects must have no skin disease in the facial area being evaluated.
• •8. Subjects must have no known medical conditions that, in the investigator's opinion, may interfere with study participation.
• •9. Subjects must be willing to provide verbal understanding and written informed consent