Morning Versus Bedtime Dosing of Antihypertensive Medication

Exclusion Criteria

• •1. Secondary hypertension;
• •2. Concomitant obstructive sleep apnea (STOP-BANG score ≥ 5), insomnia, Parkinson's syndrome, or nocturnal polyuria and other diseases that affect nighttime BP;
• •3. Need to work at night;
• •4. Ambulatory BP monitoring was invalid (\<70% valid readings, or \<20 daytime readings or \<7 nighttime readings);
• •5. Concomitant diseases that need taking medications influencing BP;
• •6. Coronary heart disease, myocardial infarction or stroke within recent 6 months;
• •7. Atrial fibrillation or frequent arrhythmia;
• •8. Abnormal liver function exemplified as an increased alanine transaminase (ALT), aspartate transaminase (AST), total bilirubin (TBL) over the double of the upper limit of normal range; abnormal renal function exemplified as a serum creatinine ≥176 µmol/L; and plasma potassium ≥5.5 mmol/L or ≤3.5mmol/L;
• •9. Pregnant or lactating women;
• •10. Contraindications of angiotensin II receptor blocker or calcium channel blocker;
• •11. Other concomitant diseases which are considered not suitable to participate in the trial, such as thyroid diseases, acute infectious diseases, chronic mental diseases, tumor, etc.