Chronic Pain Master Protocol (CPMP): A Study of LY3526318 in Participants With Osteoarthritis

Exclusion Criteria

• •Have had a procedure within the past 6 months intended to produce permanent sensory loss in the target area of interest (for example, ablation techniques).
• •Have surgery planned during the study for any reason, related or not to the disease state under evaluation.
• •Have, in the judgment of the investigator, an acute, serious, or unstable medical condition or a history or presence of any other medical illness that would preclude study participation.
• •Have had cancer within 2 years of baseline, except for cutaneous basal cell or squamous cell carcinoma resolved by excision.
• •Have fibromyalgia
• •Have a substance use disorder as defined by the Diagnostic and Statistical Manual of Mental Disorders (5th edition; DSM-5; American Psychiatric Association).
• •Have a positive human immunodeficiency virus (HIV) test result at screening.
• •Are in the judgment of the investigator, actively suicidal and therefore deemed to be at significant risk for suicide.
• •Have an intolerance to acetaminophen or paracetamol or any of its excipients.
• •Have a history of alcohol, illicit drug, analgesic or narcotic use disorder within 2 years prior to screening.
• •Are largely or wholly incapacitated and unable to participate fully in all protocol procedures, for example, bedridden or confined to a wheelchair, permitting little or no selfcare.
• •Have presence of surgical hardware or other foreign body in the index knee.
• •Have an unstable index joint (such as a torn anterior cruciate ligament).
• •Have had a surgical procedure or therapeutic injection in the affected knee within 3 months prior to starting the washout period.
• •Have chronic pain syndrome, or other concurrent medical or arthritic conditions that could interfere with the evaluation of the index knee.
• •Have a history of Reiter's syndrome, rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, arthritis associated with inflammatory bowel disease, sarcoidosis, or amyloidosis.
• •Have clinical signs and symptoms of active knee infection or crystal disease of the index knee.
• •Have a history of infection in the index joint.
• •Have a history of arthritis due to crystals (e.g., gout, pseudo gout).
• •Have pain or functional impairment due to ipsilateral hip osteoarthritis.
• •Are pregnant or breastfeeding.