Ex-vivo Primed Memory Donor Lymphocyte Infusion to Boost Anti-viral Immunity After T-cell Depleted HSCT

Inclusion Criteria

• •1. Informed consent signed by the patient (ages 14 to 18) and / or his legal representative (ages 0 to 18).
• •2. The patient has an indication for allogeneic transplantation of hematopoietic stem cells established in accordance with the current regulatory framework
• •3. Planned HSCT selective immunomagnetic depletion of alpha/betta T lymphocytes
• •4. Karnovsky or Lansky index more than 50%
• •5. Life expectancy at least 4 weeks
• •6. Heart function: ejection fraction of at least 40%
• •7. Consent to continue follow-up for 5 years