Dietary Sodium Intake and Blood Pressure in Living Kidney Donors

Exclusion Criteria

• •History of previous cardiovascular (CV) events including acute MI, HF, and stroke
• •Symptomatic heart failure within 5 months after living kidney donation or left ventricular ejection fraction (by any method) \<35%
• •CV event or procedure or hospitalization for hypertensive-related disorders within 5 months after living kidney donation
• •Diagnosed with HTN or on antihypertensive medication(s) before living kidney donation
• •Patients who are supposed to take BP lowering medications for reasons other than BP control but do not take those medications or take them with in appropriate doses
• •Arm circumference is too small or large to allow accurate BP measurement with available 24-h ABPM machines.
• •An average standing SBP ≥160 mmHg at 5-month post-donation measured by automatic office blood pressure (AOBP)
• •Albuminuria that equals or is equivalent to 1 g per day by using spot urinary albumin per urine creatinine ratio (UACR) or 24-hour urinary albumin excretion rate by a 24-hour urine collection within 5 months post-donation
• •Advanced kidney function defined by estimated glomerular filtration rate (eGFR) by using Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation22 of \<20 ml/min/1.73m2 or requiring dialysis after living kidney donation
• •Drink coffee \> two 8-ounce (237 mL) cup a day or equivalence
• •Drinks alcohol \>3 drinks/day or \>30 ml/day
• •Smoking cigarette ≥10 cigarettes/day
• •Take Nonsteroidal anti-inflammatory drugs (NSAIDS)
• •Use hormone replacement therapy or oral contraceptives
• •Pregnancy, currently trying to become pregnant
• •Using birth control pills
• •A medical condition likely to limit survival to less than 2 years
• •Any factors that are likely to limit adherence to interventions. For example,
• •* Living kidney donors who cannot come to follow up regularly per study protocol to logistically collect data from enrolled participants.
• •* Active alcohol or substance abuse within the last 5 months of living kidney donation
• •* Plans to move outside the clinic catchment area in the next 4 months without the ability to transfer to come to follow up at SPLID study site.
• •* Significant history of poor adherences with medications or attendance at clinic visits
• •* Significant concerns about participation in the study from spouse, significant other, or family members
• •* Lack of support from primary health care provider
• •* Residence too far from the study clinic site such that transportation is a barrier including persons who require transportation assistance provided by the SPLID clinic funds for screening or randomization visits
• •* Residence in a nursing home or an assisted living
• •* Clinical dementia with or without treatment with medications and cognitively unable to follow the protocol
• •* Other medical, psychiatric, or behavioral factors that may interfere with study participation or the ability to follow the intervention protocol
• •* Inability to obtain informed consent from participant
• •* Living in the same household as an already randomized SPLID participant