IntraDermal Versus Intramuscular Comirnaty® Efficacy Study

The 8-week, Prospective, Randomized controlled of IntraDermal administration of Comirnaty® 6 microgram compare to Intramuscular Comirnaty® 30 microgram by 28 days interval Efficacy Study in healthy volunteer.To compare the AntiSpike antibody, ( Anti RBD ) neutralized antibody ( if possible) of SAR-CoV-2 and T-cell response after injection with Intradermal Comirnaty® 6 microgram versus Intramuscular Comirnaty® 30 microgram by 28 days interval in healthy volunteer in various immunological background groups.1000 patients with or with out vaccinated and with our without history of previous COVID-19 infection (in various immunological background ) will be recruited and received Comirnaty® 6 microgram versus Intramuscular Comirnaty® 30 microgram by 28 days interval Inclusion Criteria: 1. Signed informed consent by any patient capable of giving consent, or, when the patient is not capable of giving consent, by his or her legal/authorized representatives prior to initiation of any study procedures. 2. Men and women, ≥18 years of age at time of enrollment. 3. Able to follow up the vaccination schedule. Exclusion Criteria: 1. Patient with known hypersensitivity or intolerance to Comirnaty® or Polyethylene glycol (PEG). 2. Patient with previous receiveing mRNA vaccine ( Pfizer, Moderna or other). 3. Pregnancy with gestational age less than 12 weeks. 4. Patient with History of immunosuppessive drug ( oral , IV, IM ) of which discontinue less than 6 month or any immunological abnormality which impact to Antibody production and T cell function ( eg hypergammaglobulinemia, active immne deficiency). 5. Patient with previous used of Intravenous immunoglobulin in previous 6 month 6. Patient with history of abnormal coagulation or contraindication for intramuscular injection or intradermal injection. 7. Patient with end stage disease or disease with life expectancy less than 2 years 8. Patient with previous use of medication interfere with serum interferon other cytokine system or disease with cytokine abnormalities. 9. Patient with history of abnormal platelet or platelet dysfunction, blood coagulopathy abnormality. 10. Patient with active pulmonary tuberculosis or systemic tuberculosis, atypical non mycobacterium tuberculosis. Primary efficacy: To compare the AntiSpike antibody, ( Anti RBD ) neutralized antibody ( if possible) of SAR-CoV-2 and T-cell response after injection with Intradermal Comirnaty® 6 microgram versus Intramuscular Comirnaty® 30 microgram by 28 days interval in healthy volunteer in various immunological background groups. Secondary efficacy: Comparesion of infection rate in each arm.