Clareo Health | REstrictive Versus LIberal Oxygen Strategy and Its Effect on Pulmonary Hypertension After Out-of-hospital Cardiac Arrest (RELIEPH-study)
Unconsciousness (Glasgow coma scale \<8) after sustained ROSC
You may not be if
Conscious patients (obeying verbal commands)
Females of childbearing potential (unless a negative HCG test can rule out pregnancy within the inclusion window)
In-hospital cardiac arrest
OHCA of presumed non-cardiac cause e.g. after trauma or dissection/rupture of major artery or cardiac arrest caused by initial hypoxia (i.e. drowning, suffocation, hanging).
Known bleeding diathesis (medically induced coagulopathy (e.g. warfarin, NOAC, clopidogrel) does not exclude the patient)
Suspected or confirmed acute intracranial bleeding
Suspected or confirmed acute stroke
Unwitnessed asystole
Known limitations in therapy and Do Not Resuscitate-order
Known disease making 180 days survival unlikely
Known pre-arrest cerebral performance category 3 or 4
\>4 hours (240 minutes) from ROSC to screening
Systolic blood pressure \<80 mmHg in spite of fluid loading/vasopressor and/or inotropic medication/intra-aortic balloon pump/axial flow device
