Laser Interstitial Thermal Ablation and Stereotactic Radiosurgery for Patients With Spine Metastases

Exclusion Criteria

• •Quantification of the degree of epidural spinal cord compression as grade 1C, 2, or 3 by MRI, with and without contrast sequences. Axial T2 sequence is encouraged but not required.
• •The vertebral body site to be treated must be located from T2 to L1
• •No more than 3 contiguous or dis-contiguous vertebral levels involved with metastasis in the spine to be irradiated in a single session or 3 sessions.
• •Motor strength ≥4 out of 5 in extremity or extremities affected by the level of the spinal cord compression (see section 4 for grading method).
• •ECOG performance status \<2 or Karnofsky performance status (KPS) \>50
• •Life expectancy \>3 months.
• •Inoperable disease because of patient refusal, neurosurgical evaluation, or any other medical reasons.
• •Women of child-bearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) before study entry and for the duration of study participation. Should a woman become pregnant or suspect she is pregnant while she or her partner is participating in this study, she should inform her treating physician immediately.
• •Prior conventional radiation to the same site is allowed as long as there is a greater than 3 months interval.
• •Signed informed consent.
• •Requires open spinal procedure or a percutaneous procedure without the use of image guidance.
• •Primary tumors of radiosensitive histology (lymphoma, multiple myeloma, small cell carcinoma, germ cell tumors), as conventional radiation is likely to be effective in such cases.
• •Unable to tolerate general anesthesia and prone position.
• •Unable to undergo MRI scan of the spine.
• •Inability to lie flat on a treatment table for \>60 minutes.
• •Pregnant. (Urine testing must be done no more than 10 days prior to surgery.)
• •Prior conventional irradiation of the spine site and level to be treated with an interval shorter than 3 months.
• •Frank cord compression or cord compression from bone components or configuration and acute neurological deficits (defined as motor strength \<4/5 in extremity or extremities affected by the level of the spinal cord compression)