Finding studies
Finding studies
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Shenmiao Yang, MD.
CONTACT
Xiaojun Huang, MD. PhD.
CONTACT
Lead
Peking University People's Hospital
CD147 has been demonstrated higher and relatively specific expression on T cell non-Hodgkin's lymphoma. Preclinical studies have shown that CAR T cells targeting CD147 antigen can continuously eliminate Jurkat T-cell lymphoma in mice and extend survival without severe adverse events including hemolysis. Preliminary investigation of CD147-CAR T cells in solid tumors has started and shown an acceptable safety profile. The safety and preliminary effectiveness of CD147-CAR T cells in patients with relapsed or refractory T cell non-Hodgkin's lymphoma will be investigated in this pioneering study.
Age
18–65
Sex
ALL
Healthy volunteers
Not accepted
