Efficacy and Biomarkers of Response of TBS in Treatment Resistant Depression

Participants will receive 22 bilateral sessions of sham/active continuous (right DLPFC) and intermittent (left DLPFC) TBS during 6 weeks. Simultaneous cerebral PET-MRI will be performed before (week 0) and after the treatment with TBS (week 7) * Weeks 1 and 2: 1 session 5 days a week (10 sessions) * Weeks 3,4,5, 6: 1 session 3 days a week (12 sessions)