A Multistrain Probiotic in Patients With Irritable Bowel Syndrome With Predominant Constipation

Exclusion Criteria

• •CPRu \> 10 mg/l
• •Pregnant or breastfeeding woman, woman planning a pregnancy during the study period ;
• •Intolerance or proven food allergy ;
• •BMI \<18.5 kg / m2 or BMI\> 35 kg / m2 ;
• •Diagnosis or known history of IBS-D, IBS-M, or unclassified forms of IBS, or other gastrointestinal pathologies ;
• •With current first-line IBS-C treatment or second-line treatment ;
• •alternative non pharmacological treatment ;
• •Drug treatment affecting visceral sensitivity or intestinal transit ;
• •dietary modification (exclusion of FODMAPs, prebiotic) or lifestyle ;
• •Excessive smoking or drinking ;
• •Having or planning bariatric surgery,
• •With known pathologies affecting gut function ;
• •With a deviant eating behavior,
• •Treated with antibiotics in the 3 months preceding inclusion,
• •Under legal protection,
• •Already included in a clinical trial,
• •With severely impaired physical/psychological health may affect study participation.