Isometric Exercise for People With Raised Blood Pressure

Exclusion Criteria

• •Currently taking anti-hypertensive medication
• •White coat hypertension, as evidenced by averaged home systolic BP \<135 mmHg
• •Inability to undertake study intervention (isometric exercise)
• •Previous history of any of the following:
• •* Diabetes mellitus (Type 1 or type 2)
• •* Ischaemic heart disease (myocardial infarction and/or coronary angina and/or coronary revascularization procedure)
• •* Moderate or severe stenotic or regurgitant heart valve disease
• •* Atrial or ventricular arrhythmia
• •* Stroke or transient ischaemic attack
• •* Aortic aneurysm and/or peripheral arterial disease
• •* Uncorrected congenital or inherited heart condition
• •Estimated glomerular filtration rate \<45 ml/min (calculated using CKD-EPI or MDRD formulae, and taking most recent documented results)
• •Documented left ventricular ejection fraction \<45% and/or left ventricular hypertrophy (by either echocardiography or standard ECG criteria e.g. Sokolow-Lyon)
• •Documented urine albumin:creatinine ratio \>3.5 mg/mmol
• •Inability to provide informed consent
• •If female, pregnancy or currently breast feeding
• •Enrolled in another Clinical Trial of an Interventional Medicinal Product or Medical Device or other interventional study
• •Medical condition that, in the opinion of the investigator, would make the participant unsuitable for the study