Liver Adiposity Effects on Pediatric Statin

Exclusion Criteria

• •Pregnancy
• •Non-fasting
• •Non-removable metal in body or MRI unsafe
• •Currently on statin therapy and unwilling to wash out of statin therapy for at least 4 weeks prior to Visit 1 and throughout the duration of the study.
• •Underlying unrepaired congenital or acquired cardiovascular defects or repaired congenital or acquired cardiovascular defects with hemodynamically significant residual disease.
• •History of underlying or laboratory evidence of underlying intestinal, metabolic, autoimmune, renal disease that can alter rosuvastatin disposition\* (absorption, metabolism, distribution, or clearance)
• •Pharmacotherapy that interacts with statins (OATP1B1 inducers/inhibitors) \*
• •Inability to swallow a tablet
• •\>5x the age-specific upper limit of normal for AST, ALT, total and conjugated bilirubin
• •Diarrhea in the last 24 hours
• •Anything that would exclude a participant from completing an MRI, such as pacemakers, claustrophobia, or body habitus (e.g., weight greater than 350 lbs.)