A Study of LNK01002 in Patients With Primary or Secondary Myelofibrosis,Polycythemia Vera or Acute Myeloid Leukemia

Exclusion Criteria

• •1. Allergic to any component of LNK01002.
• •2. Serum total bilirubin greater than 1.5 times the upper limit of the normal (ULN) reference range, except patients diagnosed as Gilbert's disease
• •3. ALT or AST higher than 3 times the ULN reference range without hepatic involvement by leukemia, which are excluded if higher than 5 times the ULN
• •4. Glomerular filtration rate or estimated creatinine clearance \< 50 mL/min according to the Cockcroft-Gault formula;
• •5. Serum amylase or lipase levels higher than the ULN and considered clinically significant
• •6. International normalized ratio (INR) or partial activated prothrombin time (aPTT) above 1.5 times the ULN reference range
• •7. Known history of clinically significant liver disease, including viral or other hepatitis:
• •a) Patients with hepatitis B or hepatitis C may be enrolled if they have a negative polymerase chain reaction (PCR)
• •8. Known human immunodeficiency virus (HIV) infection;
• •9. Clinically significant cardiovascular diseases, including acute myocardial infarction, unstable angina, coronary artery bypass surgery within 6 months before enrollment, congestive heart failure with New York Heart Association (NYHA) classification of III or above, left ventricular ejection fraction (LVEF) \< 50%, or uncontrolled hypertension, cardiac arrhythmia;
• •10. Patients with history or presence of clinically relevant non-malignant CNS disease requiring treatment;
• •11. Patients who have received systemic antineoplastic therapy or radiotherapy within 2 weeks prior to start of study treatment;
• •12. Patients who have received hematopoietic stem cell transplantation (HSCT) within 60 days prior to the start of study treatment, or are receiving immunosuppressive therapy after HSCT at screening, or have graft-versus-host disease (GVHD) requiring ongoing treatment;
• •13. Received anti-tumor Chinese herbal medicine treatment within 1 week before the start of study treatment;
• •14. Received CYP3A strong inhibitors or strong inducers less than one week or 5 half-lives (whichever is longer) prior to the start of study treatment;
• •15. Uncontrolled, active infections requiring intravenous antibiotic treatment;