Long-term Effect of a 3-month Supplementation With Holo-BLG on House Dust Mite Induced Allergic Rhinoconjunctivitis

Exclusion Criteria

• •Persons \<18 years
• •lack of verbal and written consent
• •persons who do not speak German
• •seriously ill persons
• •Persons with immunosuppressive medication such as systemic corticosteroids, cyclosporine
• •Pregnancy and breastfeeding
• •psychiatric illness
• •Persons who have received or have started sublingual or subcutaneous immunotherapy (SLIT/SCIT) against house dust mites in the last 2 years before screening
• •Contraindications and/or history of adrenaline intolerance and/or emergency medication.
• •Concurrent use of anti-allergic medications and/or inadequate washout period of these anti-allergic medications prior to the selection process and exposure in the exposure chamber
• •Use of an investigational drug 30 days/5 half-lives of the drug (whichever is longer) prior to screening
• •Use of certain drugs prior to V5: Systemic corticosteroids within 3 weeks; Topical nasal corticosteroids within 2 weeks; Chromones within 7 days; Antihistamines within 72h; Antibiotics within 3 months; Pro-, Pre- and Synbiotics 1 month