The Effect of Tobacco Products on Wound Healing

Exclusion Criteria

• •* Any tattoos on the medial upper arm (note that one medial upper arm can have a tattoo, but at least one side does not have a tattoo).
• •* History of delayed wound healing.
• •* Intention to quit normal tobacco product use in the next three months.
• •* Excessive drinking (more than 21 alcoholic drinks per week)
• •* Taking exclusionary medications (including anti-inflammatory agents) unstable dosing of medications, or unstable control of symptoms for ongoing medical conditions (medications or conditions that would impact biomarkers or patient safety to be determined by the licensed medical professional at each site).
• •* Active infection (e.g., influenza, cold, respiratory infection, sinus infection), admission to study will be delayed pending improved health;
• •* Individuals with extremely sensitive skin that may feel the 45 degrees Celsius is too warm
• •* Pregnant or breastfeeding or plans to become pregnant
• •2. For participants enrolled in an active Tobacco Research Programs study:
• •\- Pregnant or breastfeeding or plans to become pregnant
• •* Regular use of other tobacco or smoked products (e.g., cigars, pipes, smokeless tobacco, marijuana) in past 6 months;
• •* Active infection (e.g., influenza, cold, respiratory infection, sinus infection), admission to study will be delayed pending improved health;
• •* Unstable medical or psychiatric condition
• •SMOKERS
• •Inclusion:
• •\- Currently smoking at least 10 cigarettes per day;
• •\- History of at least 5 years smoking;
• •\- Stable smoking pattern for the past 1 year (\<50% change in brand or number of cigarettes smoked).
• •FORMER SMOKERS
• •Inclusion:
• •* History of smoking at least 10 cigarettes per day;
• •* Quitting over 1 year ago
• •NEVER SMOKERS
• •Exclusion:
• •\- Smoking more than 100 cigarettes in their lifetime
• •NICOTINE REPLACEMENT USERS
• •\- Inclusion/Exclusion dependent on intended sample use
• •E-CIGARETTE USERS (Addendum study) - Inclusion/Exclusion dependent on intended sample use
• •SMOKELESS TOBACCO USERS (Addendum study)
• •\- Inclusion/Exclusion dependent on intended sample use
• •\- Daily proton pump inhibitor, H2-blocker (i.e., ranitidine, famotidine), and/or calcium carbonate use
• •\- History of gastric bypass surgery, gastric banding, bowel resection, malabsorption syndromes such as celiac sprue or pancreatic insufficiency, or other conditions that may affect gastric or intestinal absorption of nutrients
• •\- Use of tobacco products other than cigarettes (i.e. snuff, snuz, smokeless tobacco, cigars, pipes), within 7 days of study registration
• •* Major or chronic medical disease, including heart disease, poorly controlled diabetes, etc., to be adjudicated by the principal investigator
• •* Known active malignancy
• •* History of aerodigestive malignancies
• •* Pregnancy, intension to become pregnant within 3 months of study registration, or lactation. Participants of childbearing potential must have a negative urine pregnancy test within 14 days of starting the assigned intervention
• •* Antibiotic use within 2 months of study registration by self-report
• •* History of respiratory tract cancer
• •* Known allergy to I3C, Sil, or its components
• •* Psychiatric and/or social situations that would potentially limit compliance with study requirements
• •\- Any tattoos on the medial upper arm (note that one medial upper arm can have a tattoo, but at least one side does not have a tattoo).
• •\- History of delayed wound healing.
• •* Individuals with extremely sensitive skin that may feel the 45 degrees Celsius is too warm