A Study to Evaluate Safety and Effectiveness of G-POEM for Gastroparesis

Exclusion Criteria

• •Another active disorder which could explain symptoms in the opinion of the investigator.
• •Gastric retention of solids at 4 hours \< 25% or \< 75% at 2 hours.
• •Ongoing use of prokinetic agents (e.g., metoclopramide, erythromycin, prucalopride) GLP -1 analog or agonists, or drugs that slow down gastric emptying (narcotics). Neuromodulators such as tricyclic antidepressants (amitriptyline or nortriptyline) or others that are being used at stable doses for a month prior to randomization may continue at the discretion of the care provider.
• •Significant systemic illness such as chronic renal failure (adjusted for age) or liver disease as defined by Child-Pugh score of 10 or greater.
• •Poorly controlled diabetes with HbA1c of greater than 10% at time of screening.
• •New medications for gastroparesis-related symptoms started within 1 month prior to registration.
• •Pregnancy or nursing.
• •Failure to give informed consent.
• •Any other condition, which in the opinion of the investigator would impede compliance or hinder completion of the study.
• •Botox injection into the pylorus within 3 months prior to registration.
• •Allergy to eggs or Egg Beaters and Ensure.