A Trial of SHR-1703 in Healthy Subjects

Exclusion Criteria

• •1. Known history or suspected of being allergic to the study drug.
• •2. Positive hepatitis B virus (HBsAg), hepatitis C virus (HCV-Ab), human immunodeficiency virus (HIV-Ab) at screening.
• •3. Participation in clinical trials of other investigational drugs or medical devices within 3 months prior to screening or within 5 half-lives of any drugs during screening visit, or in the follow-up period of a clinical study whichever is longer
• •4. Use of any medicine within 4-weeks prior to the IP administration
• •5. Blood donation or loss of more than 400 mL of blood within 1 month of screening; or received blood transfusion within 2 months before screening.
• •6. Live (attenuated) vaccination within 1 month before screening or plan to be vaccinated
• •7. Severe injuries or major surgeries within 6 months before screening or plan to do surgeries during the trial
• •8. Patients with known or suspected parasitic infection within 6 months before screening
• •9. Either ALT, AST, ALP, GGT or total bilirubin level exceeds upper limit of normal range (ULN) at screening or baseline visits (confirmed by a single repeat, as per investigator's judgment)
• •10. More than 5 cigarettes daily (or products with equivalent amount of nicotine) for 3 months prior to screening.
• •11. History of alcohol abuse within 3 months prior to the IP administration