Active uncontrolled psychological disturbances identified by current psychiatric admission

Psychiatric consult during admission, or need for hospital appointed sitter during admission

Non-English speakers requiring a translator

Current corticosteroid use or corticosteroid use during the study period (including betamethasone for promoting fetal lung maturity)

Cognitive impairment identified by medical chart review or patients requiring a legal guardian for medical decision making

Self-reported hypersensitivity to hydrocortisone

Inability to consent patient and administer study drug within 12 hours of a traumatic event

Weight \< 45 kilograms (kg) or \>120kg

Subjects with systemic active infections (e.g. viral, bacterial, fungal, protozoan, or helminthic)

Subjects with uncontrolled hypertension, renal insufficiency, or decompensated congestive heart failure

Subjects with inflammatory bowel disease

Subjects with active or latent peptic ulcers

Glucocorticoid Administration After Traumatic Birth