To Evaluate the Safety, and Pharmacokinetics of Parscaclisib in Participants With Normal Hepatic Function and Hepatic Impairment.

Exclusion Criteria

• •Evidence of rapidly deteriorating hepatic function.
• •Participants with serum calcium and phosphorus levels over the upper limits of the institutional normal ranges.
• •History or current diagnosis of uncontrolled or significant cardiac disease indicating significant risk of safety for participation in the study, including any of the following:
• •Participants who have a current, functioning organ transplant or have a scheduled organ transplant in the next 6 weeks from check-in.
• •History of malignancy within 5 years of screening, with the exception of cured basal cell carcinoma, squamous cell carcinoma of the skin, ductal carcinoma in situ, or Gleason 6 prostate cancer.
• •History of clinically significant gastrointestinal disease or surgery (cholecystectomy and appendectomy are allowed) that could impact the absorption of study drug.
• •Participants with severe ascites or an encephalopathy ≥ Grade 2.
• •Any major surgery within 4 weeks of screening.
• •Donation of blood to a blood bank within 4 weeks of screening (within 2 weeks for plasma only).
• •Blood transfusion within 4 weeks of check-in. Current or recent history (within 30 days before screening) of a clinically significant bacterial, fungal, parasitic, or mycobacterial infection, or currently receiving systemic antibiotics. Current clinically significant viral infection at screening or check-in.
• •Positive serology for hepatitis B virus (eg, hepatitis B surface antigen) or human immunodeficiency virus. Participants whose results are compatible with immunity due to infection or prior immunization for hepatitis B may be included at the discretion of the investigator.
• •History of alcoholism within 3 months of screening.
• •Positive breath test for ethanol or positive urine screen for drugs of abuse that is not otherwise explained by permitted concomitant medications.
• •Current treatment or treatment within 30 days or 5 half-lives (whichever is longer) of study drug administration with another investigational medication or current enrollment in another investigational drug protocol.
• •Current treatment or treatment within 30 days or 5 half-lives (whichever is longer) of study drug administration with strong or moderate inducer or potent inhibitor of CYP3A4.
• •Receipt of live (including attenuated) vaccines or anticipation of need for such a vaccine during the study. (Note: Non-live or inactivated vaccines allowed up to 2 weeks before first dose administration.)
• •Known hypersensitivity or severe reaction to parsaclisib or excipients of parsaclisib.
• •History of any significant drug allergy (such as anaphylaxis or hepatotoxicity) deemed clinically relevant by the investigator. Inability to be venipunctured or tolerate venous access.
• •Participants eligible for Group 4 who have a history or presence of liver disease or liver injury as indicated by an abnormal clinically significant liver function profile at screening or check-in.
• •Participants eligible for Group 4 who have a positive test for hepatitis C virus.
• •Participants eligible for Group 4 who used tobacco- or nicotine-containing products within 6 months of screening.
• •Women who are pregnant or breastfeeding