Pharmacodynamic Evaluation of Intranasal Nalmefene

Exclusion Criteria

• •History of clinically significant disease
• •Significant trauma injury, major surgery, open biopsy within 30 days prior to screening
• •Subject who has a difficult airway for intubation.
• •Following an abnormal diet 4 weeks prior to screening
• •Use of over-the-counter medications, dietary supplements, herbal products, vitamins or opioid analgesics 14 days before intervention
• •Use of enzyme altering drugs 30 days before intervention
• •Use of nasal products 28 days before intervention and throughout the study
• •Previous or current opioid, alcohol, or other drug dependence
• •Donated or received blood 30 days before intervention
• •Women who are pregnant or breastfeeding at screening
• •Women of childbearing potential unless surgically sterile or use effective contraception
• •Current or recent upper respiratory tract infection
• •Allergic to nalmefene or naloxone or known hypersensitivity reaction to plastics.