Mass Balance Study of [14C] TAS-205 in Healthy Volunteers

Exclusion Criteria

• •1. Had current or previous hypersensitivity or allergy to drugs
• •2. Had current or previous drug abuse (including use of illicit drugs) or alcoholism
• •3. Had any concurrent disease (including symptoms and signs; however, diseases that do not affect valuations in the study such as asymptomatic pollinosis and wart are excluded)
• •4. Consumed foods or beverages containing the St. John's Wort within 28 days before study drug administration
• •5. Had blood pressure, pulse rate, and body temperature meeting any of the following at screening:
• •Systolic blood pressure: \<90 mmHg or ≥140 mmHg, Diastolic blood pressure: \<40 mmHg or ≥90 mmHg, Pulse rate: \<40 beats per minute (bpm) or ≥100 bp, Body temperature: 35.0°C or ≥37.1°C