An averaged magnetization inversion recovery acquisitions (AMIRA) sequence was proposed for SC MRI. This MR-sequence delivers excellent contrast between the SC gray and white matter as well as between the SC and cerebrospinal fluid (CSF) in clinically feasible-acquisition times. Moreover, the high quality and in-plane resolution of AMIRA images allows for segmentation of the SC gray and white matter with high accuracy and reproducibility. This study is to evaluate the sensitivity and intra-/inter-observer agreement of the averaged magnetization inversion recovery acquisitions (AMIRA) in spinal cord (SC) Multiple sclerosis (MS) lesion detection and to evaluate the additional clinical value of this sequence in clinical settings.
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Diagnosis of multiple sclerosis according to established international criteria
Steroid free period: \> 4 weeks
Participation in the Swiss MS Cohort (SMSC) study
You may not be if
. History of severe (other) neurological, internal or psychiatric disease with SC affection
1. Paramagnetic and/or superparamagnetic foreign objects in the body (especially when located close to the SC)
2. Pacemaker
3. Claustrophobia
4. Pregnancy, lactation
5. Known hypersensitivity to gadolinium-based contrast media
Clareo Health | Spinal Cord Lesion Detection in Multiple Sclerosis Using Novel MRI Sequences
