SPARK-ALL: Calaspargase Pegol in Adults With ALL

Exclusion Criteria

• •Patients with Philadelphia chromosome positive ALL, Burkitt's leukemia, mixed lineage/mixed phenotype acute leukemia, and acute undifferentiated leukemia per WHO classification (2016).
• •Patients with Down syndrome.
• •Patients with Hepatitis B (positive for HBs antigen), and Hepatitis C (HCV antibody) at inclusion
• •Participants known to be HIV-positive.
• •Known history of non-gallstone-related pancreatitis.
• •Known severe hepatic impairment (bilirubin \>3 x upper limit of normal \[ULN\]; transaminases \>10 times ULN.
• •Pre-existing history of hepatic veno-occlusive disease (VOD).
• •Age ≥ 55 years.
• •BMI \> 35 kg/m2.