QUantitative Flow Ratio Or Angiography for the assessMent of nOn-culprit Lesions

Exclusion Criteria

• •Stenoses or patients a priori not amenable to treatment with PCI (at the discretion of two interventional cardiologists - e.g. patients with limited life expectancy, stenosis in very small vessels, very diffuse disease with complex/very calcified stenosis requiring surgery etc).
• •Persistent symptoms or evidence of ischemia requiring intervention of the non-culprit lesion.
• •Any contraindication to PCI according to guidelines
• •An ACS in the period following the index ACS and randomization
• •TIMI (Thrombolysis in Myocardial Infarction) flow grade \< 3 in the culprit vessel
• •Presence of thrombus in the non-culprit lesion
• •Participation in another randomized interventional study interfering with the present protocol
• •Patient unable to give informed consent
• •Women of child-bearing potential or lactating
• •Previous coronary artery bypass surgery CABG
• •Recent (within 30 days) unsuccessful PCI
• •Decompensated congestive heart failure (CHF) or hospitalization due to CHF during the last 3 months
• •Left ventricular ejection fraction \<30%
• •Severe chronic obstructive pulmonary disease (COPD)
• •Severe valvular heart disease
• •FFR (or RFR, iFR etc) assessment of non-culprit lesions at the time of the index procedure