Phase Ib Clinical Study of Keynatinib

Exclusion Criteria

• •Cohort 1: R/R-PCNSL
• •1. PCNSL is pathologically diagnosed as T-cell lymphoma;
• •2. Have previously received any of the following treatments:
• •1. Chemotherapy, targeted therapy, radiotherapy or antibody based anti-tumor therapy are used within 4 weeks before the first administration or within 5 half-lives (whichever is shorter);
• •2. Have previously received the treatment of B Cell Receptor (BCR) inhibitors (such as BTK, phosphoinositide kinase 3 kinase \[PI3K\] or SYK inhibitors) or BCL-2 inhibitors (such as ABT-199) or Chimeric Antigen Receptor T-Cell Immunotherapy (CAR-T) or a bispecific antibody drug;
• •3. Have received Allogenetic Haematopoietic Stem Cell Transplantation (Allo-HSCT) or other organ transplants (except for those who have received ASCT more than six months);
• •3. Take ≥ 8 mg dexamethasone or equivalent daily to control lymphoma symptoms;
• •4. CNS external beam radiotherapy within 21 days before the first administration;
• •5. The systemic immunosuppressants, including cyclosporine A, tacrolimus, sirolimus and other drugs, haven't stopped 28 days before the first use of the study drug, or \> 5 mg/day of prednisone or its equivalent has been taken for long period;
• •6. Have other malignant tumors within 3 years, except for the curable basal or squamous cell skin cancer, superficial bladder cancer, carcinoma in situ of cervix or breast;
• •7. Non-hematologic toxicity of the previous anti-tumor treatment has not recovered to ≤ grade 1 (except for hair loss);
• •8. Have uncontrollable or severe cardiovascular disease, including:
• •1. Congestive heart failure with New York Heart Association (NYHA) grade II or higher, unstable angina, myocardial infarction within 6 months before first study drug administration, or arrhythmia requiring treatment during screening, Left Ventricular Ejection Fraction (LVEF) \<50% ;
• •2. Primary cardiomyopathy (such as dilated cardiomyopathy, hypertrophic cardiomyopathy, arrhythmogenic right ventricular cardiomyopathy, restrictive cardiomyopathy, and atypical cardiomyopathy);
• •3. Clinically significant QTc interval prolonged medical history, or the QTc interval of screening period \> 470 ms in female, and \> 450 ms in male;
• •4. Uncontrollable high blood pressure (on the basis of improving life style, with 2 or more antihypertensive drugs (including diuretics) that will be reasonably tolerable and sufficient for more than one month being applied, the blood pressure has not reached to the standard yet, or the blood pressure could only be effectively controlled by taking 4 or more antihypertensive drugs);
• •9. Have active bleeding within 2 months before screening or are taking anticoagulant/antiplatelet drugs, or the investigators believe that there is a clear bleeding tendency (such as esophageal varices with bleeding risk, or a locally active ulcer lesions);
• •10. Have medical history of deep vein thrombosis or pulmonary embolism;
• •11. Have medical history of stroke or intracranial hemorrhage within 6 months before taking the study drug, except for intracranial hemorrhage due to surgical sequelae;
• •12. Have clinically significant gastrointestinal abnormalities, which might affect drug intake, transport or absorption (such as inability to swallow, chronic diarrhea, intestinal obstruction, etc.);
• •13. Have serious or active infection requiring systematic anti infection treatment;
• •14. At screening, patients with active uncontrolled infection \[such as infection that requiring intravenous antibiotic therapy, human immunodeficiency virus (HIV), hepatitis B virus (HBV) or hepatitis C virus (HCV) infection, etc.\]; Note: If hepatitis B virus surface antigen (HBsAg) is positive, HBV-DNA \< 1000 cop/ml, and ALT/AST ≤ 2.0 × ULN can be included. HCV infection is defined as HCV-Ab positive.
• •15. Have past history of or current pulmonary fibrosis, interstitial pneumonia, pneumoconiosis, radiation pneumonia, drug-related pneumonia, severe impairment of lung function, etc;
• •16. Have undergone major surgery or have not recovered from the invasive operation within 4 weeks before taking the study drug for the first time and are not suitable for the clinical trial according to the judgment of the investigators;
• •17. Who is participating in other clinical studies or have participated in other intervention clinical trials within 4 weeks before screening;
• •18. Have history of alcohol or drug abuse;
• •19. Pregnant or lactating women;
• •20. Concomitant administration of drugs with moderate to severe inhibition or strong induction of cytochrome P450 CYP3A
• •21. Subjects determined by the investigators to be unsuitable for other reasons;
• •Cohort 2: R/R-CLL/SLL
• •1. Have medical history of prolymphocytic leukemia, known medical history of Richter syndrome or currently suspected Richter transformation (patients with clinical suspicion need biopsy to exclude transformation)
• •2. Have previously received any of the following treatments:
• •1. Chemotherapy, targeted therapy, radiotherapy or antibody-based anti-tumor therapy within 4 weeks or 5 half-lives (whichever is shorter) before the first administration;
• •2. Previous treatment with BTK, phosphoinositide kinase 3 kinase \[PI3K\] or SYK inhibitors or BCL-2 inhibitors (such as ABT-199) or chimeric antigen receptor T cell immunotherapy (CAR-T) or treatment with bispecific antibody drugs;
• •3. Patients who received allogeneic hematopoietic stem cell transplantation (Allo-HSCT) or other organ transplantation within the past 6 months;
• •4. Patients who received autologous hematopoietic stem cell transplantation within the past 6 months;
• •3. Use of systemic corticosteroids within 7 days before the first administration of study drug, or continuous use of prednisone at or above 20 mg/day or equivalent;
• •4. Other malignancies within 3 years, except for curable basal or squamous cell skin cancer, superficial bladder cancer, and carcinoma in situ of the uterine cervix or breast;
• •5. Non-hematologic toxicity of the previous anti-tumor treatment has not recovered to ≤ grade 1 (except for hair loss);
• •6. Have uncontrollable or severe cardiovascular disease, including:
• •1. Congestive heart failure with New York Heart Association (NYHA) grade II or higher, unstable angina, myocardial infarction within 6 months before first study drug administration, or arrhythmia requiring treatment during screening period, Left Ventricular Ejection Fraction (LVEF) \<50%;
• •2. Primary cardiomyopathy (such as dilated cardiomyopathy, hypertrophic cardiomyopathy, arrhythmogenic right ventricular cardiomyopathy, restrictive cardiomyopathy, and atypical cardiomyopathy);
• •3. Clinically significant QTc interval prolonged medical history, or the QTc interval of screening period \> 470 ms in female, and \> 450 ms in male;
• •4. Uncontrollable high blood pressure (on the basis of improving life style, with 2 or more antihypertensive drugs (including diuretics) being applied that will be reasonably tolerable and sufficient for more than one month, the blood pressure has not reached to the standard yet, , or the blood pressure could only be effectively controlled by taking 4 or more antihypertensive drugs);
• •7. Have active bleeding within 2 months before screening or is taking anticoagulant/antiplatelet drugs, or the investigators believe that there is a clear bleeding tendency (such as esophageal varices with bleeding risk, or a locally active ulcer lesions);
• •8. Active and/or persistent autoimmune anemia and/or autoimmune thrombocytopenia requiring treatment (e.g., idiopathic thrombocytopenic purpura);
• •9. Have medical history of deep vein thrombosis or pulmonary embolism;
• •10. Have medical history of stroke or intracranial hemorrhage within 6 months before taking study drug;
• •11. Have clinically significant gastrointestinal abnormalities, which might affect drug intake, transport or absorption (such as inability to swallow, chronic diarrhea, intestinal obstruction, etc.);
• •12. Have active infection requiring systemic anti-infective treatment;
• •13. At screening, patients with active uncontrolled infection \[such as intravenous infection that requiring antibiotic therapy, human immunodeficiency virus (HIV), hepatitis B virus (HBV) or hepatitis C virus (HCV) infection, etc.\]; Note: If hepatitis B virus surface antigen (HBsAg) is positive, HBV-DNA \< 1000 cop/ml, and ALT/AST ≤ 2.0 × ULN can be included. HCV infection is defined as HCV-Ab positive.
• •14. Have past history of or current pulmonary fibrosis, interstitial pneumonia, pneumoconiosis, radiation pneumonia, drug-related pneumonia, severe impairment of lung function, etc;
• •15. Have history of alcohol or drug abuse;
• •16. Have undergone major surgery or have not recovered from the invasive operation within 4 weeks before taking the study drug for the first time and are not suitable for the clinical trial according to the judgment of the investigators;
• •17. Whowill participating in other clinical studies or haveparticipated in other intervention clinical trials within 4 weeks before screening;
• •18. Pregnant or lactating women;
• •19. Concomitant administration of drugs with moderate to severe inhibition or strong induction of cytochrome P450 CYP3A;
• •20. Subjects determined by the investigators to be unsuitable for other reasons;
• •Cohort 3: R/R-MCL
• •1. Havepreviously received any of the following treatments:
• •1. Chemotherapy, targeted therapy, radiotherapy or antibody based anti-tumor therapy are used within the first 4 weeks or 5 half-lives (whichever is shorter) before the first administration;
• •2. Have previously received the treatment of BTK, phosphoinositide kinase 3 kinase \[PI3K\] or SYK inhibitors) or BCL-2 inhibitors (such as ABT-199) or Chimeric Antigen Receptor T-Cell Immunotherapy (CAR-T) or received bispecific antibody drug;
• •2. Use of systemic corticosteroids at or above 20 mg/day prednisone or equivalent within 7 days before the first administration of study drug;
• •3. Have other malignant tumors within 3 years, except for the curable basal or squamous cell skin cancer, superficial bladder cancer, carcinoma in situ of cervix or breast ;
• •4. Non-hematologic toxicity of the previous anti-tumor treatment has not recovered to ≤ grade 1 (except for hair loss);
• •5. Have uncontrollable or severe cardiovascular disease, including:
• •1. Congestive heart failure with New York Heart Association (NYHA) grade II or higher, unstable angina, myocardial infarction within 6 months before first study drug administration, or arrhythmia requiring treatment during screening period, Left Ventricular Ejection Fraction (LVEF) \<50% ;
• •2. Primary cardiomyopathy (such as dilated cardiomyopathy, hypertrophic cardiomyopathy, arrhythmogenic right ventricular cardiomyopathy, restrictive cardiomyopathy, and atypical cardiomyopathy);
• •3. Clinically significant QTc interval prolonged medical history, or the QTc interval of screening period \> 470 ms in female, and \> 450 ms in male;
• •4. Uncontrollable high blood pressure (on the basis of improving life style, with 2 or more antihypertensive drugs (including diuretics) that will be reasonably tolerable and sufficient for more than one month being applied, the blood pressure has not reached to the standard yet, , or the blood pressure could only be effectively controlled by taking 4 or more antihypertensive drugs);
• •6. Have medical history of deep vein thrombosis or pulmonary embolism;
• •7. Have medical history of stroke or intracranial hemorrhage within 6 months before taking study drug;
• •8. Have clinically significant gastrointestinal abnormalities, which might affect drug intake, transport or absorption (such as inability to swallow, chronic diarrhea, intestinal obstruction, etc.);
• •9. Have serious or active infection requiring systematic anti infection treatment;
• •10. At screening, patients with active uncontrolled infection \[such as infection that requiring intravenous antibiotic therapy, human immunodeficiency virus (HIV), hepatitis B virus (HBV) or hepatitis C virus (HCV) infection, etc.\]; Note: If hepatitis B virus surface antigen (HBsAg) is positive, HBV-DNA \< 1000 cop/ml, and ALT/AST≤ 2.0 × ULN can be included. HCV infection is defined as HCV-Ab positive.
• •11. Have past history of or current pulmonary fibrosis, interstitial pneumonia, pneumoconiosis, radiation pneumonia, drug-related pneumonia, severe impairment of lung function, etc;
• •12. Have history of alcohol or drug abuse;
• •13. Have undergone major surgery or have not recovered from the invasive operation within 4 weeks before taking the study drug for the first time and is not suitable for the clinical trial according to the judgment of the investigators;
• •14. Who is participating in other clinical studies or have participated in other intervention clinical trials within 4 weeks before screening;
• •15. Pregnant or lactating women;
• •16. Concomitant administration of drugs with moderate to severe inhibition or strong induction of cytochrome P450 CYP3A;
• •17. Subjects determined by the investigators to be unsuitable for other reasons;