Lead Sponsor

Centre Hospitalier Universitaire, Amiens

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Yes

•Patients having a consultation in the Research and Resources Memory Center of Amiens (RRMC) ,
•patients registered in the Alzheimer National Bank and having an Alzheimer Disease based on NIA-AA (McKahnn2011)and IWG2 (Dubois et al, 2014) criteria or, having a Lewy body disease based on revised criteria of McKeith et al 2020
•patients having a complete neuropsychological evaluation including a visual inspection time.
•patients having a MMSE ≥ 18/30 so as to ensure a good homogeneity of the group and to have an adequate ocular exam's quality.
•patients having an available MRI in the CHU's database including a 3DT1 sequence
•patients having a visual acuity better than 5/10, spherical refraction of +/- 5D, an astigmatism \< 3D and an applanation IOP \<22mmHg

•Any other neurocognitive disorder
•Any other optical neuropathy including glaucoma
•All kind of retinal disease (diabetic retinopathy, age-related macular degeneration…)
•Diabetes mellitus
•Uncontrolled hypertension blood pressure
•Any ophthalmological conditions interfering with a good ocular examination or OCT quality (cataract, corneal opacity..)
•Severe dementia preventing a good ophthalmological examination
•Not consenting patient
•Patient with guardianship or curatorship having symptoms preventing a good ophthalmological examination (agitation, unstable ocular fixation)